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Applied Biological Chemistry

Table 1 List of cyclohexenone derivatives

From: Anticancer activities of cyclohexenone derivatives

Derivative

Name

IC50/μM

logP

MW

1

ethyl 3-(2-hydroxyphenyl)-5-(naphthalen-1-yl)-2-cyclohexenone-6-carboxylate

89.39

4.48

386.44

2

ethyl 3-(2-hydroxy-6-methoxyphenyl)-5-(naphthalen-1-yl)-2-cyclohexenone-6-carboxylate

127.35

4.35

416.47

3

ethyl 3-(2-hydrox-4,5-dimehoxyyphenyl)-5-(naphthalen-1-yl)-2-cyclohexenone-6-carboxylate

7.83

4.22

446.49

4

ethyl 3-(2-hydroxy-4,6-dimethoxyphenyl)-5-(naphthalen-1-yl)-2-cyclohexenone-6-carboxylate

Note determined

4.22

446.49

5

ethyl 3-(2-hydroxy-4-methoxyphenyl)-5-(naphthalen-1-yl)-2-cyclohexenone-6-carboxylate

110.81

4.35

416.47

6

ethyl 3-(2-hydroxyphenyl)-5-(naphthalen-2-yl)-2-cyclohexenone-6-carboxylate

90.00

4.48

386.44

7

ethyl 3-(2-hydroxy-6-methoxyphenyl)-5-(naphthalen-2-yl)-2-cyclohexenone-6-carboxylate

98.37

4.35

416.47

8

ethyl 3-(2-hydroxy-4,5-dimethoxyphenyl)-5-(naphthalen-2-yl)-2-cyclohexenone-6-carboxylate

1.03

4.22

446.49

9

ethyl 3-(2-hydroxy-4-methoxyphenyl)-5-(naphthalen-2-yl)-2-cyclohexenone-6-carboxylate

122.81

4.35

416.47

10

ethyl 3-(2-hydroxyphenyl)-5-(2-methoxynaphthalen-1-yl)-2-cyclohexenone-6-carboxylate

108.18

4.35

416.47

11

ethyl 3-(2-hydroxy-5-methoxyphenyl)-5-(2-methoxynaphthalen-1-yl)-2-cyclohexenone-6-carboxylate

5.34

4.22

446.49

12

ethyl 3-(2-hydroxy-6-methoxyphenyl)-5-(2-methoxynaphthalen-1-yl)-2-cyclohexenone-6-carboxylate

80.07

4.22

446.49

13

ethyl 3-(2-hydroxy-4,5-methoxyphenyl)-5-(2-methoxynaphthalen-1-yl)-2-cyclohexenone-6-carboxylate

1.74

4.10

476.52

14

ethyl 3-(2-hydroxy-4,6-dimethoxyphenyl)-5-(2-methoxynaphthalen-1-yl)-2-cyclohexenone-6-carboxylate

133.12

4.10

476.52

15

ethyl 3-(2-hydroxyphenyl)-5-(naphthalen-1-yl)-2-cyclohexenone-6-carboxylate

72.87

4.35

416.47

16

ethyl 3-(2-hydroxyphenyl)-5-(4-methoxynaphthalen-1-yl)-2-cyclohexenone-6-carboxylate

2.27

4.22

446.49

17

ethyl 3-(2-hydroxy-6-methoxyphenyl)-5-(4-methoxynaphthalen-1-yl)-2-cyclohexenone-6-carboxylate

115.37

4.22

446.49

18

ethyl 3-(2-hydroxy-4,6-dimethoxyphenyl)-5-(4-methoxynaphthalen-1-yl)-2-cyclohexenone-6-carboxylate

115.09

4.10

476.52

19

ethyl 3-(2-hydroxy-6-methoxyphenyl)-5-(2,3-dimethoxynaphthalen-1-yl)-2-cyclohexenone-6-carboxylate

85.88

4.10

476.52

20

ethyl 3-(1-hydroxynaphthalen-2-yl)-5-(2-methoxyphenyl)- 2-cyclohexenone-6-carboxylate

72.18

4.35

416.47

21

ethyl 3-(2-hydroxy-4-methoxyphenyl)-5-(2-methoxynaphthalen-1-yl)-2-cyclohexenone-6-carboxylate

0.93

4.22

446.49

  1. IC50, half-maximal inhibitory concentrations values by in vitro acetylcholinesterase enzyme assay; logP, the logarithm of partition coefficient values calculated using the Sybyl/MOLCAD module; MW, molecular weight
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