Evaluation of the hepato-renal functions and antimicrobial activity of fatty amido benzoic acid synthesised from Citrullus colocynthis seed oil

Applied Biological Chemistry

Table 5 Plasma clinical parameters in rats following 14 days treatment with FBA

Parameters	A	B	C	D
AST, U/l	104.8 ± 6.1	111.9 ± 12.8	104.8 ± 8.1	200.6 ± 18.7**
ALT, U/I	43.0 ± 6.1	72.1 ± 3.4*	71.2 ± 10.3*	84.7 ± 3.4**
Total Bilirubin	14.6 ± 1.4	14.6 ± 1.2	14.8 ± 1.1	17.5 ± 1.1
Albumin, g/dl	3.2 ± 0.1	1.6 ± 0.1**	3.1 ± 0.1	3.2 ± 0.1
Creatinine, µmol/l	88.4 ± 8.7	100.8 ± 8.8	115.4 ± 6.4	118.1 ± 6.9*
Urea, mmol/l	0.7 ± 0.02	1.2 ± 0.01**	1.1 ± 0.03**	1.3 ± 0.02**
Potassium, mEq/l	1.9 ± 0.2	2.5 ± 0.2*	2.8 ± 0.01**	2. 7 ± 0.1**
Sodium, mEq/l	140.7 ± 2.8	138.7 ± 3.4	140.1 ± 3.1	133.0 ± 0.1

Values are expressed as mean ± SE for five rats in each group. A, Control; B, FBA (10 mg kg⁻¹); C, FBA (50 mg kg⁻¹); D, FBA (100 mg kg⁻¹); *significantly different from control (p < 0.05). **Significantly different from control (p < 0.01)