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Applied Biological Chemistry

Table 1 The IC50 and selectivity index (SI) of curcumin, trienone 4, and trienone 11 in CLS-354/DX and CLS-354/WT

From: A trienone analog of curcumin, 1,7-bis(3-hydroxyphenyl)-1,4,6-heptatrien-3-one, possesses ROS- and caspase-mediated apoptosis in human oral squamous cell carcinoma cells in vitro

Compound

IC50 (μM)

Selectivity index (SI)

CLS-354/DX

CLS-354/WT

Vero

CLS-354/DX

CLS-354/WT

Curcumin

47.54 ± 1.42aA

13.31 ± 1.24aB

35.41 ± 1.23aC

0.7

2.6

Trienone 4

36.58 ± 1.02bA

23.81 ± 1.03bB

> 50bC

1.4

2.1

Trienone 11

16.50 ± 1.03cA

10.09 ± 1.06cB

33.89 ± 6.83aC

2.0

3.4

  1. Values are expressed as mean ± standard deviation (SD) of duplicate sample in three independent experiments. Different lower-case letters above values indicate statistically significant difference (p < 0.05) in the same column, and different upper-case letters above values indicate statistically significant difference (p < 0.05) in the same row
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