Fig. 3
From: MicroRNA clustering on the biogenesis of suboptimal microRNAs
Characteristics of cluster assistance. A Mutation in the basal stem of helper hairpin makes it a less optimal substrate for Microprocessor. The expression level of the recipient hairpin decreased as a result. B Increase in the length of linker region between the helper and recipient hairpins made the expression of the recipient hairpin decrease. C Cluster assistance still remains for a certain stretch of time even after the helper hairpin is cleaved by Microprocessor. D It has been shown that there are numerous examples of clustered genes, other than miR-451 and miR-144, that support the existence of cluster assistance