Skip to main content

Table 3 Summary of studies included in the systematic review

From: Dietary phytochemicals as a promising nutritional strategy for sarcopenia: a systematic review and meta-analysis of randomized controlled trials

ID

Study (ref)

Subjects

Sample sizea

Agea (years)

Phytochemical

Intervention

Exercise program

Duration (week)

Country

Measured outcomesb,c

Muscle mass

Muscle strength

Physical performance

1

Park et al. [31]

Postmenopausal women

24/21

62.8  ±  6.5/63.4  ±  6.0

Schisandra chinensis (schizandrin)

1 g/day or placebo

12

Korea

HGS

OLST

2

Kinoshita et al. [32]

Healthy women

37/36

71.3  ±  5.1/71.0  ±  5.4

Glycyrrhiza glabra L. (glabridin)

300 mg/day or placebo

Resistance training program (twice a week)

16

Japan

MM

HGS, KESb

OLSTb

3

Varma et al. [33]

Healthy older adults

15/15

69.8  ±  5.0/69.8  ±  5.0

Turmeric (curcuminoids)

500 mg/day or placebo

12

India

HGSb

4

Lim et al. [34]

Healthy older adults

18/18

63.6  ±  1.4/64.7  ±  1.2

Korean mistletoe (chlorogenic acid)

2 g/day or placebo

Resistance training program (three times a week)

12

Korea

MMc, FM, FFMc, LMc, SMIc

HGS, KESc

TUGc, 6MWT

5

Kim et al. [35]

Healthy women

32/32

80.0  ±  4.0/80.2  ±  5.6

Green tea (catechins)

350 ml/day or placebo

Exercise program (twice a week)

12

Japan

MMc

HGS, KES

TUGc

6

Wattanathorn et al. [36]

Healthy older adults

15/15

62.7  ±  6.3/64.2  ±  7.0

Kaempferia parviflora (methoxyflavone)

100 ml/day or placebo

8

Thailand

HGS

30-SCSTc, 6MWT

7

Aubertin-Leheudre et al. [37]

Sarcopenic-obese women

12/6

58.0  ±  5.0/58.0  ±  5.0

Soy (isoflavones)

90 mg/day or placebo

24

Canada

FM, FFMb

8

Ha et al. [38]

Healthy women

37/36

74.1  ±  4.7/76.0  ±  5.5

Burdock (isoflavones)

70 mg/day or placebo

Aqua exercise program (three times a week)

12

Korea

HGSd

TUGd, 6MWT, 30-SCST

9

Schrager et al. [39]

Healthy older adults

15/15

69.5  ±  9.3/68.4  ±  7.7

Blueberries (anthocyanins)

6 cups of flash-frozen blueberries/week or placebo (carrot juice)

6

USA

HGS

10

Munguia et al. (study 1) [40]

Healthy older adults

20/20

63.6  ±  2.4/63.0  ±  3.3

Cocoa (proanthocyanidins, epicatechin)

Cocoa powder containing flavonoids (179 mg/day) or placebo (an alkalinized natural cocoa powder, no-flavonoids)

12

USA

SMI

HGS

TUGc

11

Munguia et al. (study 2) [40]

Healthy older adults

34/27

76.1  ±  5.4/75.6  ±  6.2

See ID 10 (above)

See ID 10 (above)

8

USA

HGS

TUGb, 6MWTb, 30-SCSTb, 2MSTb

12

Kim et al. [41]

Healthy older adults

6/6

65.0  ±  5.0/69.2  ±  3.1

Onions, Allium cepa L. (flavonoids)

200 mg/day or placebo

Walking exercise program (three times a week)

12

Korea

MMc, FM

HGS

TUG, 30-SCSTc, 2MSTc

13

Terauchi et al. [42]

Healthy women

30/29

49.8  ±  4.7/49.8  ±  5.2

Grape seed (proanthocyanidin)

36 g/day or placebo

8

Japan

MMb, FM, LMb

14

Choquette et al. [43]

Overweight-to-obese postmenopausal women

10/12

59.0  ±  5.0/60.0  ±  5.0

Soy (isoflavones)

70 mg/day or placebo

Exercise program (three times a week)

24

Canada

LM

HGS

30-SCST

  1. MM muscle mass; FM fat mass; FFM fat-free mass; LM lean mass; SMI skeletal muscle index; HGS handgrip strength; KES knee extension strength; TUG timed up-and-go test; 6MWT 6-min walk test; 30-SCST 30-s chair stand test; OLST one-leg standing time; 2MST 2-min step test
  2. aNumber in phytochemical group/placebo group
  3. bSignificantly improved indices in phytochemical treatment group compared to placebo group
  4. cSignificantly improved indices after phytochemical supplementation for intervention period