Table 4 The AMES test result of the chalcones for mutagenicity prediction along with other toxicity profiles
Ligands | AMES toxicity | hMTD | hERG I inhibitor | hERG II inhibitor | ORAT (log LD50) | ORCT (log LOAEL) | Hepatotoxicity | Skin Sensitisation | T. Pyriformis toxicity | Minnow toxicity |
|---|---|---|---|---|---|---|---|---|---|---|
1a | No | 0.646 | No | No | 2.228 | 2.203 | No | No | 1.380 | 0.262 |
1b | No | 0.830 | No | No | 2.324 | 2.321 | No | No | 1.115 | − 1.141 |
1c | No | 0.611 | No | Yes | 2.318 | 2.044 | No | No | 1.207 | − 0.820 |
2a | Yes | 0.039 | No | No | 2.485 | 1.267 | No | No | 1.231 | − 0.229 |
2b | No | 0.429 | No | Yes | 2.360 | 2.117 | No | No | 1.664 | − 0.595 |
2c | No | 0.521 | No | Yes | 2.577 | 1.164 | No | No | 0.353 | − 1.641 |
3a | No | 0.638 | No | No | 2.233 | 1.715 | No | No | 0.286 | 0.520 |
3b | No | 0.669 | No | Yes | 2.519 | 2.330 | No | No | 0.421 | − 1.293 |
3c | No | 0.502 | No | Yes | 2.524 | 2.125 | No | No | 0.419 | − 2.152 |
4b | Yes | 0.039 | No | No | 2.601 | 1.231 | Yes | No | 1.207 | − 0.232 |