A study on catalytic and non-catalytic sites of H5N1 and H1N1 neuraminidase as the target for chalcone inhibitors

Applied Biological Chemistry

Table 7 The interaction between chalcones with a diverse CYP subfamily

Ligands	CYP2D6 substrate	CYP3A4 substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
1a	No	Yes	Yes	Yes	No	No	No
1b	No	Yes	Yes	Yes	Yes	No	No
1c	No	Yes	Yes	Yes	Yes	No	No
2a	No	Yes	Yes	Yes	Yes	No	No
2b	No	Yes	Yes	Yes	Yes	No	No
2c	No	Yes	Yes	Yes	Yes	No	Yes
3a	No	No	No	No	No	No	No
3b	No	Yes	Yes	Yes	Yes	No	No
3c	No	Yes	Yes	Yes	Yes	No	Yes
4b	No	Yes	Yes	Yes	Yes	No	No

Ligands	CYP2D6 substrate	CYP3A4 substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
1a	No	Yes	Yes	Yes	No	No	No
1b	No	Yes	Yes	Yes	Yes	No	No
1c	No	Yes	Yes	Yes	Yes	No	No
2a	No	Yes	Yes	Yes	Yes	No	No
2b	No	Yes	Yes	Yes	Yes	No	No
2c	No	Yes	Yes	Yes	Yes	No	Yes
3a	No	No	No	No	No	No	No
3b	No	Yes	Yes	Yes	Yes	No	No
3c	No	Yes	Yes	Yes	Yes	No	Yes
4b	No	Yes	Yes	Yes	Yes	No	No

Ligands	CYP2D6 substrate	CYP3A4 substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
1a	No	Yes	Yes	Yes	No	No	No
1b	No	Yes	Yes	Yes	Yes	No	No
1c	No	Yes	Yes	Yes	Yes	No	No
2a	No	Yes	Yes	Yes	Yes	No	No
2b	No	Yes	Yes	Yes	Yes	No	No
2c	No	Yes	Yes	Yes	Yes	No	Yes
3a	No	No	No	No	No	No	No
3b	No	Yes	Yes	Yes	Yes	No	No
3c	No	Yes	Yes	Yes	Yes	No	Yes
4b	No	Yes	Yes	Yes	Yes	No	No

Ligands	CYP2D6 substrate	CYP3A4 substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
1a	No	Yes	Yes	Yes	No	No	No
1b	No	Yes	Yes	Yes	Yes	No	No
1c	No	Yes	Yes	Yes	Yes	No	No
2a	No	Yes	Yes	Yes	Yes	No	No
2b	No	Yes	Yes	Yes	Yes	No	No
2c	No	Yes	Yes	Yes	Yes	No	Yes
3a	No	No	No	No	No	No	No
3b	No	Yes	Yes	Yes	Yes	No	No
3c	No	Yes	Yes	Yes	Yes	No	Yes
4b	No	Yes	Yes	Yes	Yes	No	No