Applied Biological Chemistry

Table 8 The assay result of ten chalcone compounds with their R side chains as depicted in Fig. 5 (100 µg/mL) against H5N1 and H1N1 NA compared to vanillin as the positive control

From: A study on catalytic and non-catalytic sites of H5N1 and H1N1 neuraminidase as the target for chalcone inhibitors

Compounds	R₁	R₂	R₃	R₄	% Inhibition ± SE
Compounds	R₁	R₂	R₃	R₄	H1N1 NA	H5N1 NA
1a	H	OH	H	F	21 ± 7	23 ± 11
2a	H	OH	H	NO₂	16 ± 2	21 ± 2
3a	H	OH	H	COOH	19 ± 2	27 ± 0
1b	H	O-isopropyl	H	F	5 ± 8	0 ± 3
2b	H	O-cyclopentyl	H	F	69 ± 2	70 ± 1
3b	H	O-benzyl	H	F	2 ± 4	18 ± 3
4b	H	O-cyclopentyl	H	NO₂	5 ± 5	15 ± 3
1c	OCH₃	OH	H	O-butyl	83 ± 1	82 ± 3
2c	OCH₃	OH	OCH₃	O-benzyl	1 ± 4	− 2 ± 16
3c	H	OH	OCH₃	O-benzyl	2 ± 4	7 ± 8
Vanillin	–	–	–	–	86 ± 2	84 ± 4

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