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Table 4 Acaricidal activities of 5-methyhlfurfural analogues against D. farinae, D. pteronyssinus, H. longicornis and T. putrescentiae

From: Acaricidal properties of 5-methylfurfural identified from Valeriana fauriei and its structural analogues against synanthropic mites and Asian longhorned tick with color alterations

Compound

Insect

Bioassay

LD50 (95% CI)

LD90 (95% CI)

Slope  ±  SE

χ2 (df, p)

RTD

RTA

Furan

D. farinae

Contact  +  fumigant (μg/cm2)

> 110.00

D. pteronyssinus

Contact  +  fumigant (μg/cm2)

> 110.00

H. longicornis

Packet (mg/ml)

> 50.00

T. putrescentiae

Contact  +  fumigant (μg/cm2)

> 110.00

2-methylfuran

D. farinae

Contact  +  fumigant (μg/cm2)

58.84 (47.55–72.92)

119.38 (92.62–184.70)

4.17 ± 0.72

0.404 (4, 0.982)

0.3

D. pteronyssinus

Contact  +  fumigant (μg/cm2)

57.02 (45.49–71.60)

127.56 (96.83–202.80)

3.67 ± 0.60

1.179 (4, 0.882)

0.3

H. longicornis

Packet (mg/ml)

> 50.00

T. putrescentiae

Contact  +  fumigant (μg/cm2)

39.71 (31.96–49.61)

84.53 (64.73–133.05)

3.91 ± 0.65

2.338 (4, 0.674)

0.5

Furfural

D. farinae

Contact  +  fumigant (μg/cm2)

12.94 (10.50–15.88)

24.95 (19.65–37.72)

4.49 ± 0.79

0.648 (4, 0.958)

1.6

D. pteronyssinus

Contact  +  fumigant (μg/cm2)

13.25 (10.70–16.42)

26.96 (20.92–41.66)

4.15 ± 0.71

0.513 (4, 0.972)

1.3

H. longicornis

Packet (mg/ml)

> 50.00

T. putrescentiae

Contact  +  fumigant (μg/cm2)

10.36 (7.95–13.56)

31.57 (22.35–55.33)

2.65 ± 0.40

2.122 (4, 0.713)

1.8

4,5-dimethylfurfural

D. farinae

Contact  +  fumigant (μg/cm2)

9.95 (8.60–11.46)

16.30 (13.62–23.48)

5.97 ± 1.22

0.386 (4, 0.984)

2.0

D. pteronyssinus

Contact  +  fumigant (μg/cm2)

9.91 (8.43–11.61)

17.87 (14.56–26.53)

5.00 ± 0.96

1.955 (4, 0.744)

1.8

H. longicornis

Packet (mg/ml)

> 50.00

T. putrescentiae

Contact  +  fumigant (μg/cm2)

7.12 (5.67–8.92)

15.91 (12.12–25.09)

3.67 ± 0.60

1.187 (4, 0.880)

2.6

5-hydroxymethylfurfural

D. farinae

Contact  +  fumigant (μg/cm2)

53.82 (43.95–65.49)

98.31 (78.46–146.24)

4.90 ± 0.90

1.226 (4, 0.874)

0.4

D. pteronyssinus

Contact  +  fumigant (μg/cm2)

48.71 (38.98–60.46)

103.07 (79.73–158.01)

3.94 ± 0.65

2.824 (4, 0.398)

0.4

H. longicornis

Packet (mg/ml)

> 50.00

T. putrescentiae

Contact  +  fumigant (μg/cm2)

57.58 (48.58–67.05)

101.58 (84.45–139.76)

5.20 ± 0.91

4.058 (4, 0.398)

0.3

Amitraz

D. farinae

Contact  +  fumigant (μg/cm2)

a

D. pteronyssinus

Contact  +  fumigant (μg/cm2)

H. longicornis

Packet (mg/ml)

23.83 (18.67–30.46)

64.18 (47.12–105.32)

2.98 ± 0.44

3.379 (4, 0.497)

1.0

T. putrescentiae

Contact  +  fumigant (μg/cm2)

Benzyl benzoate

D. farinae

Contact  +  fumigant (μg/cm2)

12.11 (10.49–14.03)

22.94 (18.86–31.76)

4.62 ± 0.71

3.660 (4, 0.454)

1.7

D. pteronyssinus

Contact  +  fumigant (μg/cm2)

11.09 (9.62–12.77)

20.45 (17.01–27.64)

4.83 ± 0.73

3.319 (4, 0.506)

1.6

H. longicornis

Packet (mg/ml)

a

T. putrescentiae

Contact  +  fumigant (μg/cm2)

9.95 (8.49–11.48)

18.08 (15.15–24.05)

4.94 ± 0.77

1.016 (4, 0.907)

1.9

DEET

D. farinae

Contact  +  fumigant (μg/cm2)

20.26 (17.12–24.49)

44.14 (34.22–68.35)

3.79 ± 0.59

2.401 (4, 0.662)

1.0

D. pteronyssinus

Contact  +  fumigant (μg/cm2)

17.40 (15.12–20.31)

31.77 (25.98–45.00)

4.90 ± 0.79

1.301 (4, 0.861)

1.0

H. longicornis

Packet (mg/ml)

T. putrescentiae

Contact  +  fumigant (μg/cm2)

18.54 (16.01–21.85)

35.24 (28.39–51.39)

4.59 ± 0.74

2.226 (4, 0.694)

1.0

  1. RTD relative toxicity  =  LD50 value of DEET/LD50 value of each compound
  2. RTA relative toxicity  =  LD50 value of amitraz/LD50 value of each compound
  3. a–, not tested