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Table 2 Inhibitory effects of the test compounds on LPS-induced NO production in RAW264.7 and BV2 cells

From: Anti-inflammatory components isolated from Atractylodes macrocephala in LPS-induced RAW264.7 macrophages and BV2 microglial cells

Compounds

IC50 (μM)

RAW264.7

BV2

Butein

5.40 ± 0.50

4.41 ± 0.45

4

26.8 ± 3.86

26.0 ± 0.23

5

60.5 ± 16.8

46.8 ± 1.12

6

39.1 ± 3.22

37.4 ± 4.03

7

1.7% at 80 μM

20.3% at 80 μM

8

50.8 ± 7.38

35.9% at 80 μM

9

9.2% at 80 μM

27.3% at 80 μM

10

64.3 ± 12.1

24.2% at 80 μM

11

41.2 ± 4.97

47.7% at 80 μM

12

36.7 ± 4.11

35.9% at 80 μM

13

59.2 ± 14.9

25.0% at 80 μM

14

28.4 ± 6.55

29.7% at 80 μM

15

51.3 ± 7.28

38.9% at 80 μM

16

29.8 ± 2.52

58.5 ± 2.23

17

34.8 ± 2.54

72.3 ± 3.35

18

44.5 ± 4.34

41.7% at 80 μM

19

28.8 ± 3.09

45.8% at 80 μM

21

78.1 ± 23.5

36.7% at 80 μM

22

28.0 ± 2.94

47.2% at 80 μM