Fig. 1

SM ameliorates the experimental MS and regulates the inflammatory cytokines. A Clinical score of EAE after 26 days of MOG immunization and evaluated the experimental autoimmune symptoms. B–D Inflammatory cytokines such as IL-6, TNF-α, IFN-γ, IL-17, TGF-β were estimated in 13 and 26th days of MOG immunized mice and values are expressed in pg/ml. E, F SM regulates the total Th-17 population and CD4 population in EAE mice. The CD4 positive cells were counted using cell counter and it was prepared by miltenyi cell sorted system from the splenocytes. Total CD4 IFN-γ positive cells in SM treated EAE mice and EAE disease mice were evaluated using flow cytometry. The differences were considered significant when the P values were less than 0.05