Applied Biological Chemistry

Table 3 The half-maximal cell growth inhibitory concentrations (GI₅₀) and mass spectra data of compounds 1–17. All HR/MS data were collected in [M + H]⁺ mode

From: Design, synthesis, and biological evaluation of chalcones for anticancer properties targeting glycogen synthase kinase 3 beta

Compound	Mass (M + H), (calcd./found)	GI₅₀, (μM)
1	317.0177/317.0179	21.46 ± 0.17
2	253.1229/253.1230	29.59 ± 0.84
3	273.0682/273.0692	13.35 ± 0.03
4	289.1229/289.1167	172.20 ± 2.27
5	289.1229/289.1232	15.67 ± 0.02
6	303.0788/303.0811	9.49 ± 0.02
7	329.1389/329.1379	12.34 ± 0.01
8	314.1028/314.1006	4.96 ± 0.03
9	347.0283/347.0299	8.89 ± 0.09
10	283.1334/283.1350	19.49 ± 0.09
11	273.0682/273.0688	14.20 ± 0.10
12	287.1083/287.1069	7.89 ± 0.02
13	253.1229/253.1214	4.51 ± 0.02
14	284.0923/284.0902	1.33 ± 0.02
15	319.1334/319.1356	13.50 ± 0.02
16	319.1334/319.1356	10.93 ± 0.06
17	299.1283/299.1270	9.66 ± 0.06

Back to article page