MiR-516b-5p suppressed NSCLC cell progression via targeting LRRC1 in propofol-treated NSCLC cells. NSCLC cells were transfected with miRNA NC, miR-516b-5p mimic, miR-516b-5p mimic + pc-NC, or miR-516b-5p mimic + pc-LRRC1, followed by exposure to propofol. Cell viability (A), colony-forming ability (B), migration (C), invasion (D), angiogenesis (E), and cell apoptosis (F) were determined. G, H EGFA and Bcl-2 protein abundance were detected. *P < 0.05.