Fig. 4
From: CircCEP85 upregulates IGF1 expression to promote breast cancer progression via sponging miR-1193
MiR-1193 suppressed proliferation, invasion, angiogenesis, stemness and induced apoptosis of BC cells. A, B Effect of miR-1193-mimics on proliferation in BC cells was assessed by CCK8 and EDU assays; C Effect of miR-1193-mimics on apoptosis in BC cells was assessed by flow cytometry analysis; D Effect of miR-1193-mimics on invasion in BC cells was assessed by transwell assay; E Tube formation assay was conducted to detect the effects of miR-1193-mimics on HUVEC angiogenesis capability; F Sphere formation assay was performed to assess cell stemness in BC cells treated with miR-1193-mimics; G Western blot analysis was used to determine the protein levels of PCNA, cleaved caspase 3, VEGFA and Naong in BT-549 and MDA-MB-231 cells transfected with miR-NC or miR-1193. ***P < 0.001