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Applied Biological Chemistry
Fig. 2 | Applied Biological Chemistry

Fig. 2

From: Piperine increases striatal levels of DA and TH and decreases α-syn and Aβ42 deposition in PDD mice by regulting autophagy: downexpression Beclin-1 and LC3B and upexpression p62

Fig. 2

DA, MAOB, DDC, β-secretase, AChE, Aβ42, TNF-α and IL-6 levels in treated and untreated PDD mice. Piperine has effects on regulating DA metabolism and Aβ42 and anti-inflammation.Compared to the model group, DA (I) and DDC (III) levels increased (P < 0.05), MAOB (II), β-secretase (IV), AChE (V), Aβ42 (VI), TNF-α (VII) and IL-6 (VIII) levels reduced(P < 0.05) significantly in all doses of piperine treated groups. In addition, DA (I) and DDC (III) levels was less (P < 0.05), MAOB (II), β-secretase (IV), AChE (V), Aβ42 (VI), TNF-α (VII) and IL-6 (VIII) levels higher (P < 0.05) in low and medium doses of piperine treated groups than that of the 3-methyladenine (3MA) group. Besides, DA, MAO-B, DDC, β-secretase, AChE, Aβ42, TNF-α and IL-6 levels in high dose of piperine treated group was lower than that of the madopar group. *P < 0.05, **P < 0.01 vs model group; #P < 0.05, ##P < 0.01 vs 3MA group; $P < 0.05, $$P < 0.01 vs madopar group. Values are mean ± SD of 12 mice. A normal control group; B model group; C 10 mg/kg piperine group; D 20 mg/kg piperine group; E 40 mg/kg piperine group; F 3MA group; G rapamycin group; H madopar group

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