Skip to main content
Applied Biological Chemistry
Fig. 6 | Applied Biological Chemistry

Fig. 6

From: Piperine increases striatal levels of DA and TH and decreases α-syn and Aβ42 deposition in PDD mice by regulting autophagy: downexpression Beclin-1 and LC3B and upexpression p62

Fig. 6

α-syn, TH, HSP90, Beclin-1, LC3B and p62 mRNA levels and miRNA-99a-5p expression in the brain of PDD mice (n = 12). As compared to the model group, α-syn (I), HSP90 (III), Beclin-1 (IV), and LC3B (V) mRNA levels and miRNA-99a-5p (VII) expression were decreased (P < 0.01), however, TH (II) and p62 (VI) mRNA levels were increased (P < 0.05) in all doses of piperine treated groups. As compared to 3-methyladenine (3MA) group, α-syn (I), HSP90 (III), Beclin-1 (IV) and LC3B (V) mRNA levels and miRNA-99a-5p (VII) expression were increased (P < 0.05), TH (II) and p62 (VI) mRNA levels were reduced (P < 0.05) in all doses of piperine treated groups. As compared to madopar group, α-syn (I), HSP90 (III), Beclin-1 (IV),and LC3B (V) mRNA levels and miRNA-99a-5p (VII) expression were augmented (P < 0.05), TH (II) and p62 (VI) mRNA levels were dropped (P < 0.01) in all doses of piperine treated groups. *P < 0.05, **P < 0.01 vs model group; #P < 0.05, ##P < 0.01 vs 3MA group; $P < 0.05, $$P < 0.01 vs madopar group. A normal control group; B model group; C 10 mg/kg piperine group; D 20 mg/kg piperine group; E 40 mg/kg piperine group; F 3-MA group; G rapamycin group; H madopar group

Back to article page