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Fig. 3 | Applied Biological Chemistry

Fig. 3

From: Crateva unilocularis Buch-Ham leaf extract improves glucose metabolism via regulation of insulin secretion and sensitivity in vitro and in vivo

Fig. 3

Effect of CULE on cell viability (A), NO production (B), and insulin secretion (C) in cytokine-induced RINm5F pancreatic beta cells. RINm5F pancreatic beta cells were incubated with each concentration of CULE, IL-1β (2 ng/mL) and IFN-γ (100 U/mL) for 48 h. Cell viability was determined by the MTT assay. NO production was determined by a colorimetric assay. L-NAME (1 mM) was used as the positive control. Each value is the mean ± SE of four independent repeated experiments. ###p < 0.001 vs. untreated normal. *p < 0.05, **p < 0.01 vs. control

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