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Applied Biological Chemistry
Fig. 5 | Applied Biological Chemistry

Fig. 5

From: CircGAK inhibits cell growth, migration, invasion, and angiogenesis of hepatocellular carcinoma via miR-1323/HHIP axis

Fig. 5

The effects of circGAK and miR-1323 on HHIP expression. A The overlapping of different databases to predict the HCC-related genes with potential binding abilities of miR-1323. B The expression of 9 potential targets of miR-1323 in LIHC and normal tissues from the GEPIA database. C The expression of HHIP in LIHC and normal tissues from the GEPIA database. D, E HHIP mRNA level in HCC tissues by qRT-PCR. F, G Western blot analysis of HHIP protein expression in HCC tissues and cells. H The sequence of wild-type (wt) and mutant (mut) HHIP 3’UTR. I, J Verification of the interaction between miR-1323 and HHIP by dual-luciferase reporter assays. K HHIP protein levels in HCCLM6 and MHCC97-H cells of transfecting with miR-1323 or miR-NC, L as well as co-transfected with circGAK or Vector and miR-1323 or miR-NC by western blot. Data were expressed as mean ± SD

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