Fig. 9From: Regulatory effect of peroxiredoxin 1 (PRDX1) on doxorubicin-induced apoptosis in triple negative breast cancer cellsRegulatory effect of PRDX1 on doxorubicin (DOX)Â induced apoptosis in triple negative breast cancer cells (TNBC). The intracellular ROS generated by DOX inhibits PI3K/Akt signaling pathway. Knockdown of PRDX1 further promoted DOX-mediated mitochondria-dependent apoptosis by promoting ROS production Back to article page