Skip to main content
Applied Biological Chemistry
Fig. 5 | Applied Biological Chemistry

Fig. 5

From: Gryllus bimaculatus extract protects against palmitate-induced β-cell death by inhibiting ceramide synthesis

Fig. 5

Inhibition of ceramide synthesis decreases PAL-induced β-cell death. MIN6 cells were treated with 1 µM FB1 for 24 h, followed by 0.5 mM PAL for another 24 h. A Representative western blots of indicated proteins after PAL treatment in FB1-pretreated MIN6 cells. B Nitrite and C TNF-α levels were measured after PAL treatment in FB1-pretreated MIN6 cells (n = 3). Values are expressed as mean ± SEM compared to control group; **P < 0.01 and compared to PAL-treated group; ##P < 0.01. All experiments were performed in triplicate. PAL palmitate, FB1 fumonisin B1, TNF-α tumor necrosis factor-alpha, Bcl2 B-cell lymphoma 2, eIF2α eukaryotic translation initiation factor 2A, iNOS inducible nitric oxygen synthase, PERK protein kinase R-like endoplasmic reticulum kinase, Con control (untreated)

Back to article page