In vitro repress of breast cancer by bio-product of edible Pleurotus ostreatus loaded with chitosan nanoparticles

Applied Biological Chemistry

Table 2 Anticancer activity of ChNPs, PE, PELChNPs and Vinblastine sulfate against MCF-7 cells

Conc. (µg/mL)	ChNPs		PE		PELChNPs		Vinblastine sulfate
Conc. (µg/mL)	Viability %	Inhibitory %	Viability %	Inhibitory %	Viability %	Inhibitory %	Viability %	Inhibitory %
500	34.76	65.24±2.48	2.78	97.22±0.16	1.36	98.64±0.21	5.49	94.51±0.23
250	58.19	41.81±2.07	9.47	90.53±0.39	4.29	95.71±0.07	7.82	92.18±0.16
125	80.65	19.35±1.39	17.52	82.48±0.74	9.85	90.15±0.13	15.18	84.82±0.49
62.5	98.42	1.58±0.64	38.17	61.83±1.29	20.64	79.36±0.22	23.87	76.13±1.59
31.25	100	0.0	60.95	39.05±2.71	36.79	63.21±0.83	31.95	68.05±0.72
15.6	100	0.0	74.82	25.18±1.64	48.63	51.37±1.09	40.56	59.44±1.18
7.8	100	0.0	91.43	8.57±0.59	79.41	20.59±1.75	47.21	52.79±2.35
3.9	100	0.0	99.56	0.44±0.12	90.64	9.36±0.52	52.94	47.06±1.78
2	100	0.0	100	0.0	97.23	2.77±0.31	58.76	41.24±0.24
1	100	0.0	100	0.0	99.52	0.48±0.16	67.16	32.84±0.32
0	100	0.0	100	0.0	100	0.0	100	0.0
IC₅₀	337.38 ± 13.68 µg/mL		46.27 ± 1.94 µg/mL		15.25 ± 0.54 µg/mL		5.91 ± 0.43 µg/mL