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Applied Biological Chemistry

Table 4 Antioxidant effect of components from WON-21 extract

From: Beneficial effects of WON-21 on the symptoms of a hangover and identification of active compounds: experimental studies on antioxidant, anti-inflammation, and alcohol-metabolizing enzymes

Components

0 μM (%)

10 μM (%)

30 μM (%)

100 μM (%)

IC50 (μM)

3′-Hydroxypuerarin

0.00

48.9 ± 2.57*

64.5 ± 2.59*

74.6 ± 2.78*

16.3

Chlorogenic acid

0.00

46.7 ± 1.78*

75.9 ± 0.27*

79.0 ± 1.23*

16.5

Puerarin

0.00

1.1 ± 0.14

2.7 ± 0.76

3.1 ± 0.89

> 100

3′-Methoxypuerarin

0.00

14.6 ± 5.54*

33.5 ± 2.33*

52.4 ± 2.55*

46.7

Daidzin

0.00

2.7 ± 0.80

6.7 ± 0.41

7.8 ± 0.96

> 100

Rutin

0.00

49.9 ± 2.88*

72.2 ± 0.00*

73.2 ± 0.27*

12.3

Hyperoside

0.00

43.2 ± 2.33*

69.9 ± 4.06*

76.7 ± 0.14*

18.5

Taxifolin

0.00

48.2 ± 2.76*

73.5 ± 2.30*

78.3 ± 0.25*

14.1

Narirutin

0.00

3.4 ± 1.67

5.0 ± 0.52

8.2 ± 1.43

> 100

Hesperidin

0.00

2.1 ± 0.95

9.3 ± 0.58

18.6 ± 1.38

> 100

Quercetin

0.00

48.0 ± 2.54*

75.4 ± 3.14*

76.1 ± 3.48*

15.4

Apigenin

0.00

1.2 ± 1.51

4.0 ± 1.15

4.4 ± 0.63

> 100

  1. DPPH radical scavenging activity assay at various concentrations. IC50 represents the concentration that exhibits 50% of antioxidant activity. Data presented the average of three independent experiments and was analyzed using one-way ANOVA with Tukey’s post hoc
  2. *P < 0.001 compared with untreated control
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