From: Mechanism-based biomarkers for the quality control of Dangkwisoo-san: a scoping review
Target disease | Study design (sample size, n) | Intervention | Control | Effects of Dangkwisoo-san | References | |||||
---|---|---|---|---|---|---|---|---|---|---|
Intervention | Type of preparation form | Extraction method | Duration (frequency) | Outcomes | Results | |||||
Pulmonary contusion | RCT (80:I 40, C 40) | DS + Usual carea | Decoction | NA | Total 5600 ml (400 ml/day) | 2 weeks (2/day) | Usual carea | 1) Changes in serum TNF-a, IL-6, and CRP levels (1, 3, 7, and 12 days) 2) Incidence of SIRS and ARDS 3) Mortality 4) Average hospital stay | 1) p < 0.01 2) I: SIRS (n = 6), ARDS (n = 2); C: SIRS (n = 11), ARDS (n = 5) 3) None (all groups) 4) p < 0.05 | Wei, C. H [31] |
Acute lateral ankle sprain | RCT (48:I 24, C 24) | DS + Acupuncture | Powder capsule | Water | Total 37.8 g (9-capsule/day) | 7 days (3/day) | Placebo capsule + Acupuncture | 1) VAS 2) FAOS 3) Edema 4) EQ-5D-5L 5) Number of recurrent ankle sprains | 1–4) p < 0.01 5) NS | Kim, J. H [27] |
Ankle sprain | RCT (45:I 22, C 23) | DS + Acupuncture | Powder capsule | Water | Total 37.8 g (9-capsule/day) | 7 days (3/day) | Acupuncture | 1) FAOS 2) EQ-5D-5L 3) ICER 4) Costs 5) PSA | 1, 2, 4, 5) NS 3) -151348 (Korean Won/QALY) | Huang, S. Z [35] |
Bruise | Case report (1) | DS | NA | NA | NA | 10 days (NA) | NA | 1) Headache, lower back pain 2) Expiratory dyspnea 3) Groan 4) Tears 5) Food taste 6) Epigastric lumpy stiffness 7) Pressing pain 8) Heart bottom gore | 1–4, 7, 8) Disappear 5) Good 6) Soften | NA [34] |
Traumatic pneumothorax | Case series (16) | DS | Decoction | Water | Total 7~18-pack (1-pack/day) | 7~18 days (2/day) | NA | 1) Chest pain 2) Choking sensation in the chest 3) Dyspnea 4) CT examination of the right lung | 1) Disappear 2–3) Breathe smoothly 4) Clear texture | Chen, M [32] |
Peptic ulcer | Case series (60) | DS | Decoction | Water and alcohol | 28~56-pack (1-pack/day) | 4~8 weeks (NA) | NA | Effective number of people (%)b: significantly effective; effective; or non-effective | 38 (63%); 18 (30%); 4 (7%) | Shao, Y. F. [33] |