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Applied Biological Chemistry
Fig. 2 | Applied Biological Chemistry

Fig. 2

From: Paedoksan ameliorates allergic disease through inhibition of the phosphorylation of STAT6 in DNCB-induced atopic dermatitis like mice

Fig. 2

Effects of PDS on allergic disease-related mediators. A RBL-2H3 cells were sensitized with anti-DNP IgE (100 ng/mL), treated with indicated doses of PDS, and challenged with DNP-BSA (1 μg/mL). β-Hexosaminidase release was calculated relative to the control (CON) group. Data are presented as the mean ± S.D. of the duplicates. #p < 0.05 significantly greater than CON. *p < 0.05 significantly lower than the anti-DNP IgE + DNP-BSA-treated group. B Phosphorylation levels of signal transducer and activator of transcription (STAT6) in RBL-2H3 cells in response to IgE (100 ng/mL) and DNP-BSA (10 ng/mL) in the presence of indicated concentration of PDS. Results were normalized to signal transducer and activator of transcription (STAT6) expression in RBL-2H3 cells. Each bar represents the mean ± standard deviation (S.D.) of the duplicates. #p < 0.05 significantly greater than CON. *p < 0.05 significantly lower than the anti-DNP IgE + DNP-BSA-treated group

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