Table 1 Inhibitions of MAO-A and MAO-B by ferulic acid hydrazide derivatives
Compound | R | Residual activities at 10 μM (%) | IC50 (μM) | SI | ||
|---|---|---|---|---|---|---|
MAO-A | MAO-B | MAO-A | MAO-B | |||
FA1 | 3-Br | 35.79 ± 4.57 | 91.61 ± 3.074 | 8.05 ± 0.15 | > 40 | > 4.97 |
FA2 | 4-Cl | 121.55 ± 9.45 | 48.73 ± 2.82 | > 40 | 10.78 ± 0.12 | > 3.71 |
FA3 | (4-(O-C2H5)-3-O-CH3 | 65.36 ± 0.70 | 11.60 ± 0.24 | 19.43 ± 5.049 | 1.88 ± 0.15 | 10.34 |
FA4 | 4-C2H5 | 93.37 ± 9.37 | 62.58 ± 3.54 | > 40 | 11.48 ± 0.45 | > 3.83 |
FA5 | 4-F | 119.28 ± 13.63 | 48.49 ± 2.99 | > 40 | 7.88 ± 0.12 | > 5.08 |
FA6 | H | 116.87 ± 6.82 | 97.86 ± 1.01 | > 40 | > 40 | – |
FA7 | 4-CH3 | 105.13 ± 18.13 | 80.72 ± 1.70 | > 40 | 21.47 ± 0.45 | > 1.86 |
FA8 | 4-O-CH3 | 121.79 ± 19.94 | 81.33 ± 11.075 | > 40 | > 40 | – |
FA9 | 4-O-C2H5 | 53.57 ± 4.10 | 19.28 ± 3.41 | 11.29 ± 0.41 | 2.08 ± 0.24 | 5.43 |
FA10 | 2-thienyl | 91.18 ± 4.16 | 100.00 ± 5.37 | > 40 | > 40 | – |
Toloxatone | – | – | – | 1.646 ± 0.094 | – | |
Safinamide | – | – | – | – | 0.019 ± 0.0019 | |
Clorgyline | – | – | – | 0.0079 ± 0.00094 | – | |
Pargyline | – | – | – | – | 0.11 ± 0.011 | |