Table 1 Top 20 terms in enrichment analysis based on the high-dose ‘SDT’ and ‘HYT’ groups. Bolded terms indicate referred terms for the indication of SDT and HYT. Bolded p-values indicate significant relationship between the corresponding pathways and the drugs.
Terms | HYT 25Â mg/mL | HYT 200Â mg/mL | SDT 25Â mg/mL | SDT 200Â mg/mL | ||||
|---|---|---|---|---|---|---|---|---|
P-value | Overlap | P-value | Overlap | P-value | Overlap | P-value | Overlap | |
Olfactory transduction | 7.72E-68 | 128 | 1.14E-54 | 136 | 2.94E-88 | 180 | 1.28E-58 | 148 |
Pathways in cancer | 3.36E-05 | 27 | 3.05E-06 | 36 | 3.46E-04 | 33 | 5.03E-11 | 48 |
PI3K-Akt signaling pathway | 1.93E-05 | 22 | 1.99E-03 | 22 | 2.59E-04 | 26 | 3.18E-10 | 37 |
Neuroactive ligand-receptor interaction | 7.31E-06 | 24 | 6.72E-06 | 29 | 4.09E-09 | 37 | 1.72E-07 | 34 |
Herpes simplex virus 1 infection | 1.72E-02 | 18 | 6.67E-03 | 24 | 1.29E-03 | 28 | 1.83E-07 | 37 |
Staphylococcus aureus infection | 3.68E-09 | 18 | 3.05E-06 | 17 | 1.16E-05 | 17 | 2.35E-07 | 19 |
Calcium signaling pathway | 1.71E-02 | 12 | 5.75E-03 | 16 | 5.70E-02 | 14 | 2.73E-06 | 24 |
Human papillomavirus infection | 5.45E-05 | 21 | 1.58E-02 | 19 | 7.46E-03 | 22 | 8.79E-06 | 29 |
Aldosterone synthesis and secretion | 2.10E-01 | 5 | 1.06E-01 | 7 | 3.16E-01 | 6 | 6.17E-05 | 14 |
JAK-STAT signaling pathway | 4.03E-02 | 9 | 6.59E-03 | 13 | 3.15E-02 | 12 | 6.17E-05 | 18 |
cGMP-PKG signaling pathway | 7.92E-03 | 11 | 8.94E-01 | 6 | 7.89E-01 | 7 | 6.43E-05 | 18 |
Kaposi sarcoma-associated herpesvirus infection | 9.48E-05 | 16 | 6.61E-01 | 8 | 3.97E-03 | 17 | 1.37E-04 | 20 |
Pancreatic secretion | 5.22E-02 | 7 | 4.46E-03 | 11 | 1.21E-01 | 8 | 1.61E-04 | 14 |
Human T-cell leukemia virus 1 infection | 1.97E-02 | 12 | 2.24E-01 | 11 | 1.99E-02 | 16 | 1.61E-04 | 21 |
Salivary secretion | 3.33E-01 | 4 | 5.95E-02 | 7 | 1.00E + 00 | 3 | 2.17E-04 | 12 |
Drug metabolism - other enzymes | 6.97E-02 | 6 | 7.45E-02 | 7 | 2.24E-02 | 9 | 4.36E-04 | 12 |
Hematopoietic cell lineage | 2.84E-02 | 7 | 1.16E-02 | 9 | 5.91E-01 | 5 | 5.04E-04 | 12 |
Serotonergic synapse | 7.88E-02 | 7 | 5.37E-02 | 9 | 2.59E-04 | 15 | 5.43E-04 | 14 |
Human cytomegalovirus infection | 4.31E-04 | 16 | 6.94E-01 | 9 | 1.64E-01 | 13 | 5.68E-04 | 20 |
Apelin signaling pathway | 3.66E-01 | 5 | 4.94E-01 | 6 | 7.14E-01 | 6 | 7.84E-04 | 14 |