Regulation of appetite-related neuropeptides by herbal medicines: research using microarray and network pharmacology

Applied Biological Chemistry

Table 2 Fold-change of anorexia-associated genes in ‘SDT’ and ‘HYT’ treated cell lines compared to the control. Bolded gene symbols and fold-change values indicate significant changes in gene expression (|fold-change| > 1.5). Inference scores represent the strength of the inferred association between anorexia and the gene in the CTD database

Symbol	Category	Inference score	Fold-change				Note
Symbol	Category	Inference score	SDT 25 mg/mL	SDT 200 mg/mL	HYT 25 mg/mL	HYT 200 mg/mL	Note
Tnf	mechanism	238.84	1.02	1.31	− 1.13	− 1.01
Il1b	mechanism	228.3	− 1.17	1.41	− 1.30	− 1.32
Tac1	mechanism	119.12	− 1.17	− 1.75	− 1.11	1.01
Npy	mechanism	109.76	− 1.01	− 1.01	− 1.03	− 1.01
Npy5r			1.68	− 1.08	− 1.11	1.09	Related to NPY
Npy1r			1.93	− 1.00	1.41	1.09	Related to NPY
Npy6r			1.99	1.00	1.18	− 1.11	Related to NPY
Il2	mechanism	103.27	1.42	1.41	1.17	1.40
Il2ra			− 1.50	−1.85	− 1.70	− 1.85	Related to IL2
Crh	mechanism	99.37	− 1.03	1.01	1.00	1.14
Il1rn	therapeutic	83.17	1.02	1.24	− 1.09	1.05
Tnfrsf1a	therapeutic	74.18	− 1.01	− 1.15	1.09	1.35
Gcg	mechanism	56.98	− 1.00	− 1.35	− 1.28	− 2.26
Crhr1	mechanism	45.93	− 1.23	− 1.23	− 1.17	− 1.54
Gip	mechanism	42.47	− 1.07	− 1.43	− 1.06	− 1.41
Cck	mechanism	37.71	− 1.18	1.03	1.02	− 1.41
Crhr2	mechanism	31.94	1.01	1.54	− 1.33	1.02
Htr4	mechanism	30.24	− 1.09	1.40	1.56	− 1.03
Pyy	mechanism	26.85	− 1.31	− 1.40	− 1.44	− 1.31
Ifna2	mechanism	16.2	− 1.06	1.52	− 1.10	1.04
Ucn2	mechanism	9.16	− 1.05	− 1.09	− 1.15	1.11