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Applied Biological Chemistry
Fig. 4 | Applied Biological Chemistry

Fig. 4

From: Hypothetical protein CuvA (Rv1422) from Mycobacterium tuberculosis H37Rv interacts with uridine diphosphate N-acetylglucosamine as a key precursor of cell wall

Fig. 4

Binding of UDP moiety to MtCuvA. A Best-fit model by docking simulation of MtCuvA with UDP-moiety. Residues suggested to form the hydrogen bonds with the ligand are shown as sticks. The hydrogen bond interactions are indicated by black dotted lines with the distances. B–F Non-linear square-fit curve for the UDP binding to MtCuvA mutants. The melting profiles of H12A (B), S196A (C), T199A (D), N226A (E), and H298A (F) were monitored in the presence of increasing concentrations (0.2–8 mM) of UDP

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