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Applied Biological Chemistry
Fig. 2 | Applied Biological Chemistry

Fig. 2

From: Recent progress on drugs discovery study for treatment of COVID-19: repurposing existing drugs and current natural bioactive molecules

Fig. 2

Coronavirus life cycle starts from entering a host cell (infection) until the production and release of a new virus. The words in the blue state are the steps of viral transformation inside the host cell. The activation process begins when the viral glycoprotein attaches to hACE2 and TMPRSS2 receptors. The virus fuses into the cell by endocytosis and starts to enter the cell. Following this cellular entry, the virus undergoes an uncoating process to release its viral genome. Further, structural protein synthesis is followed by RNA packaging, budding, and assembly to form a mature virion. Exocytosis releases a new infectious virion to infect a new cell. The insert box (on the bottom right) illustrates what happens to the host cell resulting in further cell death

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