Applied Biological Chemistry

Table 1 Potential biomarkers of metabolites for filtering significantly changed by C. longa extract and demethoxycurcumin 60 µM treatment (AUC ≥ 0.7)

From: Metabolomics reveals that Curcuma longa and demethoxycurcumin inhibit HCT116 human colon cancer cell growth

CON → CL			CON → DMC60
Metabolites	AUC	Concentration changes	Metabolites	AUC	Concentration changes
Alanine^***	1.00	↑	AMP^***	1.00	↓
Arginine^***	1.00	↑	Formate^***	1.00	↓
Aspartate^***	1.00	↓	Glycine^***	1.00	↑
Betaine^***	1.00	↓	Lactate^***	1.00	↑
Creatine^***	1.00	↓	NAD + ^***	1.00	↓
Glutamate^***	1.00	↓	Succinate^***	1.00	↑
GSH^***	1.00	↑	UDP-NAG^***	1.00	↓
Glycine^***	1.00	↓	UMP^***	1.00	↓
Lactate^***	1.00	↑	Uracil^***	1.00	↑
Phenylalanine^***	1.00	↓	Uridine^***	1.00	↓
Threonine^***	1.00	↓	mI^***	1.00	↓
Uracil^***	1.00	↑	GPC^***	1.00	↓
Valine^***	1.00	↓	Aspartate^***	0.99	↓
Methionine^***	0.99	↓	Valine^***	0.97	↑
Serine^***	0.99	↓	ADP^***	0.94	↓
Taurine^***	0.99	↓	4HP^**	0.94	↓
DMA^**	0.95	↓	DMA^**	0.91	↓
Isoleucine^***	0.95	↓	Inosine^***	0.91	↓
Leucine^***	0.95	↓	Glycerol^**	0.90	↑
Histidine^**	0.92	↓	Tyrosine^***	0.90	↑
Tyrosine^***	0.92	↓	NAA^**	0.89	↓
Uridine^***	0.85	↓	ATP^**	0.86	↓
Succinate^**	0.83	↓	Acetate^**	0.84	↓
mI^*	0.82	↓	Leucine^*	0.83	↑
NAA^*	0.81	↑	Betaine	0.83	↓
GPC^*	0.80	↓	Threonine^*	0.80	↑
NAD + ^*	0.78	↑	Choline^*	0.77	↓
Formate^*	0.73	↓	Glucose	0.77	↓
ATP	0.70	↓	Histidine^*	0.76	↑
			Isoleucine	0.73	↑
			Glutamate	0.71	↑
			PC^*	0.71	↓

^*, statistically different from control group with p < 0.05; **, statistically different from CON with p < 0.01; ***, statistically different from CON with p < 0.001. DMA dimethylamine, mI myo-inositol, 4-HP trans-4-hydroxy-L-proline, GSH glutathione, PC O-phosphocholine, NAA N-acetylaspartate, GPC sn-glycerol-3-phosphocholine, UDP-NAG UDP-N-acetylglucosamine

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