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Applied Biological Chemistry
Fig. 5 | Applied Biological Chemistry

Fig. 5

From: Centella asiatica lowers body fat accumulation via regulating cholesterol homeostasis- and lipid metabolism-related genes in mice with high-fat, high-sugar diet-induced obesity

Fig. 5

Relative mRNA expression in liver tissues of mice with high-fat, high-sugar diet (HFHSD)-induced obesity that were orally treated with Centella asiatica (CA) for 12 weeks. Values are the means ± standard error of mean (SEM) for eight mice. The asterisk indicates a significant difference compared to HFHSD (* p < 0.05, *** p < 0.001). The mRNA levels of the target genes were normalized to the expression level of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the results are presented as the fold changes relative to the NOR. NOR normal diet, HFHSD (Control) HFHSD, CA-L HFHSD+CA 300 mg/kg, CA-H HFHSD+CA 600 mg/kg, PPARγ peroxisome proliferator activated receptor gamma, FAS fatty acid synthase, CD36 cluster of differentiation 36, AMPK 5ʹadenosine monophosphate activated protein kinase, SREBP-2 sterol regulatory element-binding protein 2, HMGCR 3- hydroxyl-3-methylglutaryl CoA reductase, SREBP-1C sterol regulatory element-binding protein 1C, LDLR low-density lipoprotein receptor, SCD1 stearoyl CoA desaturase 1

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