Table 1 Monoamine oxidase (MAO), cholinesterase (ChE), and β-secretase (BACE1) inhibition by the compounds a
From: Pannorin isolated from marine Penicillium sp. SG-W3: a selective monoamine oxidase A inhibitor
Compounds | Residual activity at 10 µM (%) | IC50 (µM) | SIb | |||||
|---|---|---|---|---|---|---|---|---|
MAO-A | MAO-B | AChE | BChE | BACE1 | MAO-A | MAO-B | ||
1 | 13.95 ± 1.22 | 88.38 ± 3.95 | 73.42 ± 5.22 | 95.51 ± 0.91 |  > 100 | 1.73 ± 0.31 |  > 40 |  > 23.07 |
2 | 26.98 ± 1.49 | 76.15 ± 3.22 | 65.12 ± 1.00c | 83.97 ± 2.72 | 78.19 ± 10.49 | 4.29 ± 0.55 | 23.29 ± 1.80 | 5.43 |
3 | 51.63 ± 1.00 | 94.97 ± 4.35 | 73.51 ± 3.68 | 95.51 ± 0.91 |  > 100 | 12.60 ± 0.12 |  > 40 |  > 3.18 |
4 | 77.67 ± 0.15 | 81.80 ± 3.56 | 71.44 ± 1.16 | 96.80 ± 2.72 |  > 100 |  > 40 |  > 40 | – |
5 | 88.84 ± 0.07 | 82.21 ± 1.59 | 74.18 ± 2.64 | 98.72 ± 1.81 |  > 100 |  > 40 |  > 40 | – |
6 | 57.21 ± 0.28 | 63.84 ± 0.17 | 75.64 ± 1.29 | 98.72 ± 1.81 | 88.96 ± 1.66 | 13.18 ± 0.03 | 11.82 ± 0.23 | 0.90 |
Toloxatone | – | – | – | – | – | 1.25 ± 0.23 |  > 40 |  > 32.13 |
Clorgyline | – | – | – | – | – | 0.013 ± 0.008 | 1.85 ± 0.11 |  > 142.5 |
Safinamide | – | – | – | – | – |  > 40 | 0.021 ± 0.001 |  > 1904* |
Pargyline | – | – | – | – | – | 2.403 ± 0.358 | 0.14 ± 0.01 | 17.16* |
Donepezild | – | – | 0.001 ± 0.002 | 0.180 ± 0.004 | – | – | – | – |