Investigation of safety and efficacy of febantel and fenbendazole in fish and exposure assessment

Kim, Min Ji; Kim, Ji Young; Shin, Dong Woo; Kim, Hyun-Kyung

doi:10.1186/s13765-024-00879-6

Applied Biological Chemistry

Table 3 Results of febantel exposure assessment

From: Investigation of safety and efficacy of febantel and fenbendazole in fish and exposure assessment

Commodities	MRLs	MR/TRR ratio^*	Corrected value	Intake (kg/day)		Exposure (mg/day)
Commodities	MRLs	MR/TRR ratio^*	Corrected value	Average	High	Average	High
Fish	0.05	1.00	0.05	0.0292	0.2191	0.0015	0.0110
Cattle muscle	0.10	1.00	0.10	0.0220	0.2623	0.0022	0.0262
Cattle liver	0.50	1.00	0.50	0.0001	0.1194	< 0.0001	0.0597
Cattle kidney	0.10	1.00	0.10	< 0.0001	0.0004	< 0.0001	< 0.0001
Cattle fat	0.10	1.00	0.10	0.0013	0.0007	0.0001	0.0001
Pig muscle	0.10	1.00	0.10	0.0471	0.4319	0.0047	0.0432
Pig liver	0.50	1.00	0.50	0.0001	0.0946	< 0.0001	0.0473
Pig kidney	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Pig fat	0.10	1.00	0.10	< 0.0001	0.0010	< 0.0001	0.0001
Horse muscle	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Horse liver	0.50	1.00	0.50	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Horse kidney	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Horse fat	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Sheep muscle	0.10	1.00	0.10	< 0.0001	0.0015	< 0.0001	0.0001
Sheep liver	0.50	1.00	0.50	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Sheep kidney	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Sheep fat	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Goat muscle	0.10	1.00	0.10	< 0.0001	0.2184	< 0.0001	0.0218
Goat liver	0.50	1.00	0.50	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Goat kidney	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Goat fat	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Deer muscle	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Deer liver	0.50	1.00	0.50	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Deer kidney	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Deer fat	0.10	1.00	0.10	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Chicken muscle	0.05	1.00	0.05	0.0238	0.5438	0.0012	0.0272
Chicken liver	0.50	0.29	1.72	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Chicken fat	0.05	1.00	0.05	< 0.0001	0.0044	< 0.0001	0.0002
Chicken kidney	0.05	0.18	0.28	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Eggs	1.30	1.00	1.30	0.0335	0.0449	0.0436	0.0584
Milk	0.10	0.20	0.50	0.0963	0.5533	0.0481	0.2766
Sum of exposure (mg/day)						0.3300
ADI = 0.007 mg/kg bw/day × 60 kg						0.42
Hazard Index (%)						78.6

^*Ratios of marker to total radioactive residue (MR:TRR) were obtained from EMA (2013)

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