Fig. 4
From: Hyperoside ameliorates depression-like behavior in ovariectomized mice
A schematic diagram illustrating the mechanism underlying the antidepressant effects of HYP in OVX mice. HYP upregulates nNOS expression induced by estrogen deprivation, thereby restoring NO production in the hippocampus. Subsequently, it enhances BDNF-TrkB signaling, contributing to the amelioration of depression-like behavior in OVX mice. BDNF, brain-derived neurotrophic factor; HYP, hyperoside; nNOS, neuronal nitric oxide synthase; NO, nitric oxide; OVX, ovariectomized; TrkB, tropomyosin receptor kinase B