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Anti-Helicobacter pylori diarylheptanoid identified in the rhizome of Alpinia officinarum
Journal of the Korean Society for Applied Biological Chemistry volume 52, pages 367–370 (2009)
Abstract
The antibacterial activity of materials derived from the rhizome of Alpinia officinarum (Zingiberaceae) against Helicobacter pylori ATCC 43504, ATCC 700392, and ATCC 700824 was examined using paper-disc diffusion and agar dilution methods. Results were compared with those following treatment with currently used antibiotics: amoxicillin, metronidazole, and tetracycline. The bioactive principle was characterized as the diarylheptanoid 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-l-phenyl-3-heptanone by spectroscopic analysis. This compound was isolated from A. officinarum leaves as a new anti-H. pylori principle. Against H. pylori ATCC 43504, ATCC 700392, and ATCC 700824, the antibacterial activity of the diarylheptanoid (48, 24, and 24 μg/mL) was comparable to that of metronidazole (32, 16, and 16 μg/mL) but less effective than that of either amoxicillin (0.06, 0.06, and 0.03 μg/mL) or tetracycline (0.5, 1, and 0.5 μg/mL), based on minimum inhibitory concentrations. A. officinarum rhizome-derived materials, particularly the diarylheptanoid isolated, merit further study as potential antibacterial functional food products or therapeutic products for prevention or eradication from humans from diseases caused by H. pylori.
Abbreviations
- ATCC:
-
American Type Culture Collection
- FT-IR:
-
Fourier transform infrared spectroscopy
- HPLC:
-
high-performance liquid Chromatograph
- MIC:
-
minimum inhibitory concentration;
- MS:
-
mass spectrometry
- NMR:
-
nuclear magnetic resonance spectrometry
- TLC:
-
thin-layer chromatography
- TMS:
-
tetramethylsilane
- UV:
-
ultraviolet spectroscopy
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Lee, HB., Lee, HK., Kim, JR. et al. Anti-Helicobacter pylori diarylheptanoid identified in the rhizome of Alpinia officinarum . J. Korean Soc. Appl. Biol. Chem. 52, 367–370 (2009). https://doi.org/10.3839/jksabc.2009.065
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DOI: https://doi.org/10.3839/jksabc.2009.065