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Inhibitory effects of 2-(4-chlorophenyl)-1,3-selenazol-4-one on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells
Journal of the Korean Society for Applied Biological Chemistry volume 52, pages 371–374 (2009)
Abstract
In this study, the inhibitory effects of selenium-containing heterocyclic compound, selenazol derivatives on LPS-induced nitric oxide production in macrophage cells (RAW 264.7) were assessed. Five kinds of selenazol derivatives were shown to exhibit 5.4∼41.7% of inhibitory effects at 10 μM. Among them, 2-(4-chlorophenyl)-l,3-selenazol-4-one generally evidenced a high degree of inhibitory activity with IC50=11.8 μM, and this compound also profoundly suppressed iNOS expression in LPS-treated RAW 264.7 cells. These results indicated that 2-(4-chlorophenyl)-l,3-selenazol-4-one might function as an anti-inflammatory agent via the inhibition of iNOS-mediated nitric oxide production.
Abbreviations
- iNOS:
-
inducible nitric oxide synthase
- LPS:
-
lipopolysaccharide
- L-NMMA:
-
NG-monomethyl-L-arginine
- NO:
-
nitric oxide
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Choi, S.Y., Jo, Y.O., Koketsu, M. et al. Inhibitory effects of 2-(4-chlorophenyl)-1,3-selenazol-4-one on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. J. Korean Soc. Appl. Biol. Chem. 52, 371–374 (2009). https://doi.org/10.3839/jksabc.2009.066
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DOI: https://doi.org/10.3839/jksabc.2009.066