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Polyphenols Displaying Tyrosinase Inhibition from the Seed of Psoralea corylifolia

Journal of the Korean Society for Applied Biological Chemistry volume 53, pages 427–432 (2010)Cite this article

Abstract

Three chalcones and two flavanones displaying tyrosinase inhibitory activity were isolated from the seed of Psoralea corylifolia, a cultivated edible plant. The isolated compounds were elucidated as known isovabachalcone, 4′-O-methylbavachalcone, isobavachromene, corylifolin, and bavachinin. The inhibitory potencies of the polyphenols toward monophenolase activity of mushroom tyrosinase were investigated. The inhibitory concentration (IC50) values of compounds 1–5 for monophenolase activity were determined to be 12.3, 48.8, 15.8, 23.6, and 143.9 μM, respectively. The potent inhibitors 1–4 exhibited the competitive inhibition characteristics in analysis of Lineweaver-Burks and Dixon-plot.

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Authors and Affiliations

  1. Division of Applied Life Science (BK21 Program), EB-NCRC, Institute of Agriculture and Life Science, Graduate School of Gyeongsang National University, 660-701, Jinju, Republic of Korea

    Jun Young Kim, Kyeong Yeol Oh, Ji Young Kim, Hyung Won Ryu & Ki Hun Park

  2. National Research Laboratory of Lipid Metabolism & Atherosclerosis, 305-806, Daejeon, KRIBB, Republic of Korea

    Tae-Sook Jeong

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  1. Jun Young Kim
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  2. Kyeong Yeol Oh
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  3. Ji Young Kim
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  4. Hyung Won Ryu
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  5. Tae-Sook Jeong
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  6. Ki Hun Park
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Correspondence to Ki Hun Park.

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Kim, J.Y., Oh, K.Y., Kim, J.Y. et al. Polyphenols Displaying Tyrosinase Inhibition from the Seed of Psoralea corylifolia . J. Korean Soc. Appl. Biol. Chem. 53, 427–432 (2010). https://doi.org/10.3839/jksabc.2010.066

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  • DOI: https://doi.org/10.3839/jksabc.2010.066

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