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Applied Biological Chemistry
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β-CD-mediated encapsulation enhanced stability and solubility of astaxanthin

Journal of the Korean Society for Applied Biological Chemistry volume 53, pages 559–565 (2010)Cite this article

Abstract

To expand the industrial applications of astaxanthin in the food and cosmetic sectors, inclusion complexes (ICs) of astaxanthin were prepared with various types of cyclodextrins (CDs) and characterized by HPLC with respect to water-solubility and stability. Also, their characteristics were determined through SEM scanning electron microscopy and Furier transform infrared spectrometry. Among the various CDs, β-CD was selected as the host material for the inclusion of astaxanthin. The optimum ratio of astaxanthin and β-CD for IC formation was determined as 1:200. The water-solubility of the IC of astaxanthin and β-CD (As-β-CD) was enhanced up to 110-fold compared to free astaxanthin at pH 6.5 and 25°C. The stability of the β-CD-encapsulated astaxanthin against heat, light, and oxidation was greatly enhanced by over 7-9 folds compared to free astaxanthin. Furthermore, the β-CD-encapsulated astaxanthin had high stability even at 100°C. Compared to free astaxanthin, the IC formation of free astaxanthin greatly enhanced its stability under various storage conditions such as pH, temperature, ultraviolet irradiation, and the presence of oxygen.

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Authors and Affiliations

  1. Department of Food and Biotechnology and Regional Innovation Center, Hoseo University, 336-795, Asan, Republic of Korea

    Soyoung Kim, Eunah Cho, Jimin Yoo, Eunhye Cho, Sun Ju Choi, Seok Min Son, Jin Man Lee & Hee Jeong Chae

  2. Department of Human Nutrition and Food Science, Chungwoon University, 350-701, Hongseong, Republic of Korea

    Man-Jin In & Dong Chung Kim

  3. Department of Chemical Engineering, Kongju National University, 314-401, Kongju, Republic of Korea

    Jin-Hyun Kim

Authors
  1. Soyoung Kim
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  2. Eunah Cho
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  3. Jimin Yoo
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  4. Eunhye Cho
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  5. Sun Ju Choi
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  6. Seok Min Son
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  7. Jin Man Lee
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  8. Man-Jin In
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  9. Dong Chung Kim
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  10. Jin-Hyun Kim
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  11. Hee Jeong Chae
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Correspondence to Hee Jeong Chae.

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Kim, S., Cho, E., Yoo, J. et al. β-CD-mediated encapsulation enhanced stability and solubility of astaxanthin. J. Korean Soc. Appl. Biol. Chem. 53, 559–565 (2010). https://doi.org/10.3839/jksabc.2010.086

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  • DOI: https://doi.org/10.3839/jksabc.2010.086

Key words

  • astaxanthin
  • β-cyclodextrin
  • inclusion complex
  • solubility
  • stability