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Inhibitory effects of dicaffeoylquinic acids from Artemisia dubia on aldo-keto reductase family 1b10

Journal of the Korean Society for Applied Biological Chemistry volume 53, pages 826–830 (2010)Cite this article

Abstract

The ethyl acetate fraction of Artemisia dubia showed a potent inhibitory activity on recombinant human AKR1B10 (rh AKR1B10). Due to its potency, subsequent purification of ethyl acetate fraction led to seven compounds including five dicaffeoylquinic acid (DCQA) derivatives. Compounds were identified as 3,4-dihydroxybenzoic acid (1), quercetin 3-O-β-glucose (2), 3,4-DCQA (3), 3,5-DCQA (4), 4,5-DCQA (5), 3,5-DCQA methyl ester (6), and 4,5-DCQA methyl ester (7). A series of DCQA derivatives (3-7) showed inhibitory activity on rhAKR1B10 in the range of IC50 1.24-2.29 μM, whereas 3,4-dihydroxybenzoic acid and quercetin 3-O-β-glucose showed no inhibitory activity on rhAKR1B10.

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Authors and Affiliations

  1. Natural Products Research Center, Korea Institute of Science and Technology Gangneung Institute, 210-340, Gangneung, Republic of Korea

    Hee Ju Lee, Joo Young Lee, Sang Min Kim, Chu Won Nho, Sang Hoon Jung, Dae-Geun Song, Chul Young Kim & Cheol-Ho Pan

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  1. Hee Ju Lee
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  2. Joo Young Lee
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  3. Sang Min Kim
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Correspondence to Cheol-Ho Pan.

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These three authors contribute equally to this work.

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Lee, H.J., Lee, J.Y., Kim, S.M. et al. Inhibitory effects of dicaffeoylquinic acids from Artemisia dubia on aldo-keto reductase family 1b10. J. Korean Soc. Appl. Biol. Chem. 53, 826–830 (2010). https://doi.org/10.3839/jksabc.2010.125

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  • DOI: https://doi.org/10.3839/jksabc.2010.125

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