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Trafficking inhibition of bruceanol B as a radical-producing antibiotic

An Erratum to this article was published on 17 February 2012


Bruceanol B, isolated from a soil microbe strain DS4, generated oxygen radicals in Bacillus subtilis lysates. Bruceanol B inhibited the trafficking of viral glycoprotein in virus-infected baby hamster kidney (BHK) cells. Bruceanol B also effectively inhibited syncytium formation in a dosedependent manner. However, glycoprotein synthesis was not affected by the compound. Results indicate that bruceanol B generating oxygen radical has inhibitory activity in the trafficking of viral glycoprotein of BHK cell.


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Correspondence to Dong-Sun Lee or Key Zung Riu.

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Lee, D., Boo, KH., Woo, JK. et al. Trafficking inhibition of bruceanol B as a radical-producing antibiotic. J. Korean Soc. Appl. Biol. Chem. 54, 299–301 (2011).

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