Pinoresinol diglucoside is screened as a putative α-glucosidase inhibiting compound in Actinidia arguta leaves
Journal of the Korean Society for Applied Biological Chemistry volume 57, pages 473–479 (2014)
Actinidia arguta leaves are consumed as a popular food material in Korea and have been reported to exert beneficial effects on humans due to its constituent polyphenolic compounds. In this study, the α-glucosidase inhibitory compounds in A. arguta were screened and identified through α-glucosidase-guided fractionation and metabolomic analysis. The 50% ethanol extracts of A. arguta showed strong inhibitory effect (32.6%), which was comparable to acarbose as a positive control (30.0%). Through multiple steps of fractionation, pinoresinol diglucoside and fertaric acid were identified as the major potent compounds in A. arguta inhibiting α-glucosidase activity by liquid chromatography mass spectrometry analysis and metabolomic comparison. Particularly, because pinoresinol and its glycosides have been demonstrated as α-glucosidase inhibitory agents, pinoresinol diglucoside was proposed to be a putative key compound for α-glucosidase inhibition in A. arguta. This is the first study demonstrating the anti-diabetic effect of a pinoresinol-containing fraction of A. arguta and would be useful for its application as a natural α-glucosidase inhibitor.
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Kwon, D., Kim, G.D., Kang, W. et al. Pinoresinol diglucoside is screened as a putative α-glucosidase inhibiting compound in Actinidia arguta leaves. J Korean Soc Appl Biol Chem 57, 473–479 (2014). https://doi.org/10.1007/s13765-014-4167-0