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Pinoresinol diglucoside is screened as a putative α-glucosidase inhibiting compound in Actinidia arguta leaves

Journal of the Korean Society for Applied Biological Chemistry volume 57, pages 473–479 (2014)Cite this article

An Erratum to this article was published on 22 August 2014

Abstract

Actinidia arguta leaves are consumed as a popular food material in Korea and have been reported to exert beneficial effects on humans due to its constituent polyphenolic compounds. In this study, the α-glucosidase inhibitory compounds in A. arguta were screened and identified through α-glucosidase-guided fractionation and metabolomic analysis. The 50% ethanol extracts of A. arguta showed strong inhibitory effect (32.6%), which was comparable to acarbose as a positive control (30.0%). Through multiple steps of fractionation, pinoresinol diglucoside and fertaric acid were identified as the major potent compounds in A. arguta inhibiting α-glucosidase activity by liquid chromatography mass spectrometry analysis and metabolomic comparison. Particularly, because pinoresinol and its glycosides have been demonstrated as α-glucosidase inhibitory agents, pinoresinol diglucoside was proposed to be a putative key compound for α-glucosidase inhibition in A. arguta. This is the first study demonstrating the anti-diabetic effect of a pinoresinol-containing fraction of A. arguta and would be useful for its application as a natural α-glucosidase inhibitor.

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Authors and Affiliations

  1. Department of Food Science and Technology, Chung-Ang University, Anseong, 456-756, Republic of Korea

    Dodan Kwon, Gyoung Deuck Kim, Wonseok Kang, Jeong-Eun Park, Song Hee Kim & Joong-Hyuck Auh

  2. Department of Smart Foods and Drugs, School of Food and Life Science, Inje University, Gimhae, 621-749, Republic of Korea

    Jung-In Kim

  3. Department of Food and Nutrition, Inha University, Incheon, 402-751, Republic of Korea

    Eunok Choe

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  1. Dodan Kwon
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  2. Gyoung Deuck Kim
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  3. Wonseok Kang
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  4. Jeong-Eun Park
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  5. Song Hee Kim
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  7. Jung-In Kim
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Correspondence to Joong-Hyuck Auh.

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Kwon, D., Kim, G.D., Kang, W. et al. Pinoresinol diglucoside is screened as a putative α-glucosidase inhibiting compound in Actinidia arguta leaves. J Korean Soc Appl Biol Chem 57, 473–479 (2014). https://doi.org/10.1007/s13765-014-4167-0

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